• Metabolism;

• DNA repair;

• Mitochondrial function;

• Stress resistance;

• Inflammatory regulation.

CellPlus was developed to act directly on these mechanisms, supporting cell renewal and keeping your body functioning at its best over time.

CellPlus combines four highly researched molecules:

Spermidine – activates autophagy, promoting cell renewal and defence against damage. Studies suggest positive effects on memory and cognitive function.  

Trans-Resveratrol – antioxidant that protects cells and activates SIRT1 proteins, linked to DNA stability and stress resistance. 

Nicotinamide (Vitamin B3) – precursor to NAD⁺, essential for energy production, mitochondrial function, and skin and nerve health.

Calcium-Alpha-Ketoglutarate (Ca-AKG) – supports cellular metabolism, energy processes, and reduction of inflammatory markers.

• Contributes to the normal maintenance of cellular functions;

 • Supports normal cellular mechanisms associated with healthy aging;

• Contributes to the protection of cells against oxidative stress;

• Supports the normal functioning of cellular stress resistance mechanisms;

• Contributes to the reduction of fatigue and tiredness ¹;

• Contributes to normal energy metabolism ¹;

• Supports normal cognitive and vascular function;


¹ Niacin (Vitamin B3)

• Synergistic formula;

• Solid scientific basis;

• Premium ingredients and intelligent dosages;

• Advanced nutritional formula;

• Food supplement with premium quality standards.

Cell Plus is not just a supplement: it is a formula based on robust scientific evidence, developed to act on the main cellular mechanisms that influence healthy ageing.

1. Spermidine (4 mg) – Cell Renewal and Memory

• Human studies: Older adults showed improvements in episodic memory and biomarkers of cellular aging (Wirth et al., 2020).

• Preclinical studies: Improvements in organ and brain function associated with autophagy induction (Eisenberg et al., 2009).

2. Trans-Resveratrol (150 mg) – Antioxidant Protection and Cellular Stress

• Human studies: improved insulin sensitivity, reduced inflammatory markers, and support for endothelial and cognitive function associated with SIRT1 activation and cellular stress resistance (Baur & Sinclair, 2006).

3. Nicotinamide (Vitamin B3) – Energy and Metabolic Health

• Human studies: increased NAD⁺ levels, improvements in vascular flexibility, energy metabolism, and DNA repair (Imai & Guarente, 2014; Mills et al., 2016).

• Preclinical studies: prolongation of the replicative life of human cells, reduction of ROS, and telomeric protection without increasing telomerase (Kang et al., 2006).

4. Calcium Alpha-Ketoglutarate (Ca-AKG) (750 mg) – Metabolism and Inflammation

• α-ketoglutarate (AKG) is one of the most promising molecules in the field of healthy aging, with initial clinical data demonstrating improvements in biological markers in humans (Yi et al., 2023; Große Review, 2023).

• Preclinical studies: increased healthspan and reduction of certain inflammation markers (Chin et al., 2014).

Start supporting your cells today and age healthily

Safe, premium formula based on scientific evidence. Food supplement, does not replace a balanced diet.

References

Spermidina & Autophagy

Eisenberg T, Knauer H, Schauer A, et al. (2009).
Induction of autophagy by spermidine promotes longevity.
Nature Cell Biology.
PubMed: https://pubmed.ncbi.nlm.nih.gov/19801973/

Eisenberg T, Knauer H, Schauer A, et al. (2019).
Spermidine: a physiological autophagy inducer acting as an anti-aging molecule.
Nature Reviews Molecular Cell Biology.
PubMed: https://pubmed.ncbi.nlm.nih.gov/30306826/

Hofer SJ, Daskalaki I, Bergmann M, et al. (2024).
Spermidine is essential for fasting-mediated autophagy.
Cell Metabolism.
PubMed: https://pubmed.ncbi.nlm.nih.gov/39117797/

Wirth M, et al. (2020).
Spermidine supplementation improves organ and brain function in aging animals.

SIRT1, NAD⁺ & Cell Stress

Baur JA, Sinclair DA. (2006).
Therapeutic potential of resveratrol: the in vivo evidence.

Imai S, Guarente L. (2014).
NAD⁺ and sirtuins in aging and disease.

Mills KF, et al. (2016).
Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice.

Kang HT, Lee HI, Hwang ES. (2006).
Nicotinamide extends replicative lifespan of human cells.
Aging Cell, 5(5), 423–436.
PubMed: https://pubmed.ncbi.nlm.nih.gov/16939485/

α-Cetoglutarato (AKG / Ca-AKG), Metabolism & Epigenetics

Chin RM, et al. (2014).
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.
Cell Metabolism.

Yi L, Tan B, Zhang Z, et al. (2023).
Alpha-ketoglutarate dietary supplementation to improve biological age in humans.
Nature Aging.
PubMed: https://pubmed.ncbi.nlm.nih.gov/37217632/

Yi L, Tan B, Zhang Z, et al. (2023).
Alpha-ketoglutarate as a potent regulator for lifespan and healthspan in humans.
Aging Cell.
PubMed: https://pubmed.ncbi.nlm.nih.gov/36934991/

Große Review. (2023).